Stony Coral Tissue Loss Disease (SCTLD) affects approximately half of all known stony coral species in the Caribbean region. The SCTLD epidemic started in 2014 in Florida and this aggressive disease has now spread to at least 16 Caribbean countries and territories. The number of affected Caribbean countries and territories has more than doubled in the 12 months to October 2020. We present the latest known status of this disease in the Caribbean region using the recently-developed SCTLD regional dashboard. We summarize the status of cooperation efforts to build capacity for monitoring, detection and correct identification of SCTLD, and for response including outreach and partnership efforts for prevention, treatment, rescue and restoration in the Caribbean region.